Safety, activity, and immune correlates of anti-PD-1 antibody in cancer.

Topalian, Suzanne L; Hodi, F Stephen; Brahmer, Julie R; Gettinger, Scott N; Smith, David C; McDermott, David F; Powderly, John D; Carvajal, Richard D; Sosman, Jeffrey A; Atkins, Michael B; Leming, Philip D; Spigel, David R; Antonia, Scott J; Horn, Leora; Drake, Charles G; Pardoll, Drew M; Chen, Lieping; Sharfman, William H; Anders, Robert A; Taube, Janis M; McMiller, Tracee L; Xu, Haiying; Korman, Alan J; Jure-Kunkel, Maria; Agrawal, Shruti; McDonald, Daniel; Kollia, Georgia D; Gupta, Ashok; Wigginton, Jon M; Sznol, Mario

Topalian, Suzanne L; Hodi, F Stephen; Brahmer, Julie R; Gettinger, Scott N; Smith, David C; McDermott, David F; Powderly, John D; Carvajal, Richard D; Sosman, Jeffrey A; Atkins, Michael B; Leming, Philip D; Spigel, David R; Antonia, Scott J; Horn, Leora; Drake, Charles G; Pardoll, Drew M; Chen, Lieping; Sharfman, William H; Anders, Robert A; Taube, Janis M; McMiller, Tracee L; Xu, Haiying; Korman, Alan J; Jure-Kunkel, Maria; Agrawal, Shruti; McDonald, Daniel; Kollia, Georgia D; Gupta, Ashok; Wigginton, Jon M; Sznol, Mario.

Affiliation

Topalian SL; Department of Surgery, Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21287, USA. stopali1@jhmi.edu

N Engl J Med ; 366(26): 2443-54, 2012 Jun 28.

Article in En | MEDLINE | ID: mdl-22658127

Subject(s)

Antibodies, Monoclonal/therapeutic use; Antineoplastic Agents/therapeutic use; Neoplasms/drug therapy; Programmed Cell Death 1 Receptor/antagonists & inhibitors; Adult; Antibodies, Monoclonal/adverse effects; Antibodies, Monoclonal/pharmacology; Antineoplastic Agents/adverse effects; Antineoplastic Agents/pharmacology; Carcinoma, Non-Small-Cell Lung/drug therapy; Carcinoma, Renal Cell/drug therapy; Colorectal Neoplasms/drug therapy; Dose-Response Relationship, Drug; Female; Humans; Ligands; Male; Melanoma/drug therapy; Neoplasms/metabolism; Nivolumab; Programmed Cell Death 1 Receptor/immunology; Programmed Cell Death 1 Receptor/metabolism; Prostatic Neoplasms/drug therapy

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Programmed Cell Death 1 Receptor / Antibodies, Monoclonal / Neoplasms / Antineoplastic Agents Type of study: Clinical_trials Limits: Adult / Female / Humans / Male Language: En Journal: N Engl J Med Year: 2012 Type: Article Affiliation country: United States

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