Peptides based on the presenilin-APP binding domain inhibit APP processing and Aß production through interfering with the APP transmembrane domain.

Esselens, Cary; Sannerud, Ragna; Gallardo, Rodrigo; Baert, Veerle; Kaden, Daniela; Serneels, Lutgarde; De Strooper, Bart; Rousseau, Frederic; Multhaup, Gerd; Schymkowitz, Joost; Langedijk, Johannes P M; Annaert, Wim

Esselens, Cary; Sannerud, Ragna; Gallardo, Rodrigo; Baert, Veerle; Kaden, Daniela; Serneels, Lutgarde; De Strooper, Bart; Rousseau, Frederic; Multhaup, Gerd; Schymkowitz, Joost; Langedijk, Johannes P M; Annaert, Wim.

Affiliation

Esselens C; Laboratory for Membrane Trafficking, Center for Human Genetics, Katholieke Universiteit Leuven, Leuven, Belgium.

FASEB J ; 26(9): 3765-78, 2012 Sep.

Article in En | MEDLINE | ID: mdl-22661005

Subject(s)

Amyloid beta-Peptides/biosynthesis; Amyloid beta-Protein Precursor/metabolism; Membrane Proteins/metabolism; Peptides/metabolism; Presenilins/metabolism; Protein Processing, Post-Translational; Amino Acid Sequence; Amyloid beta-Protein Precursor/chemistry; HEK293 Cells; HeLa Cells; Humans; Microscopy, Confocal; Molecular Sequence Data; Surface Plasmon Resonance

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Protein Processing, Post-Translational / Amyloid beta-Peptides / Amyloid beta-Protein Precursor / Presenilins / Membrane Proteins Limits: Humans Language: En Journal: FASEB J Journal subject: BIOLOGIA / FISIOLOGIA Year: 2012 Type: Article Affiliation country: Belgium

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