Increased levels of survivin, via association with heat shock protein 90, in mucosal T cells from patients with Crohn's disease.

de Souza, Heitor S P; West, Gail A; Rebert, Nancy; de la Motte, Carol; Drazba, Judy; Fiocchi, Claudio

de Souza, Heitor S P; West, Gail A; Rebert, Nancy; de la Motte, Carol; Drazba, Judy; Fiocchi, Claudio.

Affiliation

de Souza HS; Department of Internal Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Gastroenterology ; 143(4): 1017-26.e9, 2012 Oct.

Article in En | MEDLINE | ID: mdl-22749932

Subject(s)

Colitis, Ulcerative/metabolism; Crohn Disease/metabolism; HSP90 Heat-Shock Proteins/metabolism; Inhibitor of Apoptosis Proteins/metabolism; T-Lymphocytes/metabolism; Adolescent; Adult; Aged; Aged, 80 and over; Apoptosis Regulatory Proteins; CD2 Antigens/metabolism; CD28 Antigens/metabolism; CD3 Complex/metabolism; CD3 Complex/pharmacology; Cell Nucleus/metabolism; Cell Proliferation; Cell Survival; Cells, Cultured; Colitis, Ulcerative/immunology; Crohn Disease/immunology; Cytoplasm/metabolism; Endopeptidase K/pharmacology; Female; Humans; Inhibitor of Apoptosis Proteins/genetics; Interleukin-2/pharmacology; Intestinal Mucosa/immunology; Intestinal Mucosa/metabolism; Male; Middle Aged; Mitochondrial Proteins; Phosphorylation/drug effects; Proteolysis; RNA Interference; RNA, Messenger/metabolism; Signal Transduction; Survivin; T-Lymphocytes/drug effects; T-Lymphocytes/enzymology; Ubiquitination; Young Adult

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: T-Lymphocytes / Colitis, Ulcerative / Crohn Disease / HSP90 Heat-Shock Proteins / Inhibitor of Apoptosis Proteins Type of study: Risk_factors_studies Limits: Aged80 Language: En Journal: Gastroenterology Year: 2012 Type: Article Affiliation country: Brazil

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