Lymphocytic hypophysitis in a dog with diabetes insipidus.
J Comp Pathol
; 147(4): 503-7, 2012 Nov.
Article
in En
| MEDLINE
| ID: mdl-22789859
ABSTRACT
An 8-year-old male German longhaired pointer was referred for diabetes insipidus responsive to treatment with desmopressin. The dog had polyuria and polydipsia, exercise intolerance and a dull hair coat. Plasma concentrations of thyroid-stimulating hormone, thyroxine, growth hormone (GH) and insulin-like growth factor-1 were decreased; plasma adrenocorticotropic hormone (ACTH) was slightly elevated and plasma α-melanocyte-stimulating hormone (MSH) was within the reference range. Computed tomography revealed a heterogeneously contrast-enhancing pituitary mass compressing the hypothalamus. Transsphenoidal hypophysectomy was performed and microscopical examination of the surgical biopsy samples revealed hypophysitis without evidence of pituitary adenoma. The hypophysitis was characterized by marked lymphocytic infiltration of the adenohypophysis that contained a mixed population of neuroendocrine cells expressing GH, ACTH or α-MSH. The lymphocytes were identified as T cells, resulting in a final diagnosis of lymphocytic hypophysitis strongly resembling human primary lymphocytic hypophysitis.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pituitary Gland, Anterior
/
Lymphocytes
/
Diabetes Insipidus
/
Hypopituitarism
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
J Comp Pathol
Year:
2012
Type:
Article
Affiliation country:
Netherlands