Cardiomyocyte GTP cyclohydrolase 1 and tetrahydrobiopterin increase NOS1 activity and accelerate myocardial relaxation.

Carnicer, Ricardo; Hale, Ashley B; Suffredini, Silvia; Liu, Xing; Reilly, Svetlana; Zhang, Mei Hua; Surdo, Nicoletta C; Bendall, Jennifer K; Crabtree, Mark J; Lim, Gregory B S; Alp, Nicholas J; Channon, Keith M; Casadei, Barbara

Carnicer, Ricardo; Hale, Ashley B; Suffredini, Silvia; Liu, Xing; Reilly, Svetlana; Zhang, Mei Hua; Surdo, Nicoletta C; Bendall, Jennifer K; Crabtree, Mark J; Lim, Gregory B S; Alp, Nicholas J; Channon, Keith M; Casadei, Barbara.

Affiliation

Carnicer R; Department of Cardiovascular Medicine, University of Oxford, Level 6, West Wing, John Radcliffe Hospital, OX3 9DU, United Kingdom.

Circ Res ; 111(6): 718-27, 2012 Aug 31.

Article in En | MEDLINE | ID: mdl-22798524

Subject(s)

Biopterins/analogs & derivatives; GTP Cyclohydrolase/metabolism; Nitric Oxide Synthase Type I/metabolism; Animals; Biopterins/metabolism; Biopterins/pharmacology; Calcium/metabolism; Cells, Cultured; Enzyme Activation/drug effects; Female; GTP Cyclohydrolase/genetics; Heart/drug effects; Heart/physiology; Humans; Immunoblotting; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Myocardium/cytology; Myocardium/enzymology; Myocytes, Cardiac/enzymology; Ryanodine Receptor Calcium Release Channel/metabolism; Sarcoplasmic Reticulum/metabolism; Superoxides/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biopterins / Nitric Oxide Synthase Type I / GTP Cyclohydrolase Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: Circ Res Year: 2012 Type: Article Affiliation country: United kingdom

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