Carbonylhydrazide-based molecular tongs inhibit wild-type and mutated HIV-1 protease dimerization.

Dufau, Laure; Marques Ressurreição, Ana Sofia; Fanelli, Roberto; Kihal, Nadjib; Vidu, Anamaria; Milcent, Thierry; Soulier, Jean-Louis; Rodrigo, Jordi; Desvergne, Audrey; Leblanc, Karine; Bernadat, Guillaume; Crousse, Benoit; Reboud-Ravaux, Michèle; Ongeri, Sandrine

Dufau, Laure; Marques Ressurreição, Ana Sofia; Fanelli, Roberto; Kihal, Nadjib; Vidu, Anamaria; Milcent, Thierry; Soulier, Jean-Louis; Rodrigo, Jordi; Desvergne, Audrey; Leblanc, Karine; Bernadat, Guillaume; Crousse, Benoit; Reboud-Ravaux, Michèle; Ongeri, Sandrine.

Affiliation

Dufau L; UMR-CNRS 8076, Molécules Fluorées et Chimie Médicinale, LabEx LERMIT, Faculté de Pharmacie, Université Paris-Sud 11, 5 rue J. B. Clément, 92296 Châtenay-Malabry Cedex, France.

J Med Chem ; 55(15): 6762-75, 2012 Aug 09.

Article in En | MEDLINE | ID: mdl-22800535

Subject(s)

HIV Protease Inhibitors/chemical synthesis; HIV Protease/chemistry; Hydrazines/chemical synthesis; Naphthalenes/chemical synthesis; Peptidomimetics/chemical synthesis; Enzyme Assays; Fluorometry; HIV Protease/genetics; HIV Protease Inhibitors/chemistry; Hydrazines/chemistry; Hydrophobic and Hydrophilic Interactions; Kinetics; Models, Molecular; Molecular Conformation; Mutation; Naphthalenes/chemistry; Pepsin A/antagonists & inhibitors; Pepsin A/chemistry; Peptidomimetics/chemistry; Protein Multimerization; Renin/antagonists & inhibitors; Renin/chemistry; Stereoisomerism; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV Protease / HIV Protease Inhibitors / Peptidomimetics / Hydrazines / Naphthalenes Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2012 Type: Article Affiliation country: France

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