Effect of carbon coating on the physico-chemical properties and toxicity of copper and nickel nanoparticles.
Small
; 8(21): 3289-99, 2012 Nov 05.
Article
in En
| MEDLINE
| ID: mdl-22837153
ABSTRACT
The primary aim of these interdisciplinary studies is to investigate the effect of surface carbon coating on the physico-chemical properties and toxicity of carbon-coated and noncoated copper and nickel nanoparticles (C-Cu, Cu, C-Ni, Ni NPs) in A549 alveolar epithelial cells. Compared to Cu NPs, C-Cu NPs exhibit protection against surface oxidation, tenfold higher cellular uptake, and fourfold lower release of soluble Cu. The toxicity of C-Cu NPs and Cu NPs is associated with pronounced damage to mitochondrial function and plasma membrane integrity, respectively. Compared to Cu and C-Cu NPs, Ni and C-Ni NPs are less toxic. These studies demonstrate that correlations can be drawn between physico-chemical properties and resultant toxicity of NPs as a function of surface carbon coating.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Carbon
/
Copper
/
Metal Nanoparticles
/
Chemical Phenomena
/
Nickel
Limits:
Humans
Language:
En
Journal:
Small
Journal subject:
ENGENHARIA BIOMEDICA
Year:
2012
Type:
Article
Affiliation country:
United States