Bat3 promotes T cell responses and autoimmunity by repressing Tim-3­mediated cell death and exhaustion.

Rangachari, Manu; Zhu, Chen; Sakuishi, Kaori; Xiao, Sheng; Karman, Jozsef; Chen, Andrew; Angin, Mathieu; Wakeham, Andrew; Greenfield, Edward A; Sobel, Raymond A; Okada, Hitoshi; McKinnon, Peter J; Mak, Tak W; Addo, Marylyn M; Anderson, Ana C; Kuchroo, Vijay K

Bat3 promotes T cell responses and autoimmunity by repressing Tim-3mediated cell death and exhaustion.

Rangachari, Manu; Zhu, Chen; Sakuishi, Kaori; Xiao, Sheng; Karman, Jozsef; Chen, Andrew; Angin, Mathieu; Wakeham, Andrew; Greenfield, Edward A; Sobel, Raymond A; Okada, Hitoshi; McKinnon, Peter J; Mak, Tak W; Addo, Marylyn M; Anderson, Ana C; Kuchroo, Vijay K.

Affiliation

Rangachari M; Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Nat Med ; 18(9): 1394-400, 2012 Sep.

Article in En | MEDLINE | ID: mdl-22863785

Subject(s)

Autoimmunity/immunology; Cell Death/immunology; Membrane Proteins/metabolism; Molecular Chaperones/immunology; T-Lymphocytes/immunology; Animals; DNA-Binding Proteins/genetics; Flow Cytometry; Genetic Vectors; HEK293 Cells; Hepatitis A Virus Cellular Receptor 2; Homeodomain Proteins/genetics; Humans; Mice; Mice, Knockout; Molecular Chaperones/genetics; Molecular Chaperones/metabolism; Real-Time Polymerase Chain Reaction; Retroviridae; Statistics, Nonparametric; T-Lymphocytes/metabolism; Transcription Factors/genetics; Transduction, Genetic

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: T-Lymphocytes / Autoimmunity / Cell Death / Molecular Chaperones / Membrane Proteins Limits: Animals / Humans Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 2012 Type: Article Affiliation country: United States

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