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Comment on "Impaired respiratory and body temperature control upon acute serotonergic neuron inhibition".
Löffler, Stefan; Körber, Jochen; Nubbemeyer, Udo; Fehsel, Karin.
Affiliation
  • Löffler S; Department of Psychiatry and Psychotherapy, Clinic Offenbach, Teaching Hospital of Goethe University, D-63069 Offenbach, Germany. stefloeffler@t-online.de
Science ; 337(6095): 646; author reply 646, 2012 Aug 10.
Article in En | MEDLINE | ID: mdl-22879486
ABSTRACT
Ray et al. (Reports, 29 July 2011, p. 637) assume that clozapine-N4-oxide (CNO) represents a "biologically inert synthetic ligand" that selectively activates the M4 muscarinic receptor-based DREADD (designer receptor exclusively activated by a designer drug). In contrast, due to the redox cycling of CNO with clozapine and to their cell membrane permeability, CNO is biologically active and its conversion products are capable of undermining DREADD effects.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Respiration / Body Temperature Regulation / Serotonin / Chemoreceptor Cells / Clozapine / Neural Inhibition / Neurons Limits: Animals Language: En Journal: Science Year: 2012 Type: Article Affiliation country: Germany
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Respiration / Body Temperature Regulation / Serotonin / Chemoreceptor Cells / Clozapine / Neural Inhibition / Neurons Limits: Animals Language: En Journal: Science Year: 2012 Type: Article Affiliation country: Germany