Comment on "Impaired respiratory and body temperature control upon acute serotonergic neuron inhibition".
Science
; 337(6095): 646; author reply 646, 2012 Aug 10.
Article
in En
| MEDLINE
| ID: mdl-22879486
ABSTRACT
Ray et al. (Reports, 29 July 2011, p. 637) assume that clozapine-N4-oxide (CNO) represents a "biologically inert synthetic ligand" that selectively activates the M4 muscarinic receptor-based DREADD (designer receptor exclusively activated by a designer drug). In contrast, due to the redox cycling of CNO with clozapine and to their cell membrane permeability, CNO is biologically active and its conversion products are capable of undermining DREADD effects.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Respiration
/
Body Temperature Regulation
/
Serotonin
/
Chemoreceptor Cells
/
Clozapine
/
Neural Inhibition
/
Neurons
Limits:
Animals
Language:
En
Journal:
Science
Year:
2012
Type:
Article
Affiliation country:
Germany