D-ring modified novel isosteviol derivatives: design, synthesis and cytotoxic activity evaluation.

Zhang, Tao; Lu, Li-Hui; Liu, Hao; Wang, Jun-Wei; Wang, Rui-Xue; Zhang, Yun-Xiao; Tao, Jing-Chao

Zhang, Tao; Lu, Li-Hui; Liu, Hao; Wang, Jun-Wei; Wang, Rui-Xue; Zhang, Yun-Xiao; Tao, Jing-Chao.

Affiliation

Zhang T; College of Chemistry and Molecular Engineering, New Drug Research & Development Center, Zhengzhou University, 75 Daxue Road, Zhengzhou 450052, PR China.

Bioorg Med Chem Lett ; 22(18): 5827-32, 2012 Sep 15.

Article in En | MEDLINE | ID: mdl-22901386

Subject(s)

Antineoplastic Agents/pharmacology; Diterpenes, Kaurane/pharmacology; Drug Design; Antineoplastic Agents/chemical synthesis; Antineoplastic Agents/chemistry; Cell Line, Tumor; Cell Proliferation/drug effects; Diterpenes, Kaurane/chemical synthesis; Diterpenes, Kaurane/chemistry; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HCT116 Cells; Humans; Molecular Structure; Stereoisomerism; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Design / Diterpenes, Kaurane / Antineoplastic Agents Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2012 Type: Article

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