Synthesis and comparison of antiplasmodial activity of (+), (-) and racemic 7-chloro-4-(N-lupinyl)aminoquinoline.

Rusconi, Chiara; Vaiana, Nadia; Casagrande, Manolo; Basilico, Nicoletta; Parapini, Silvia; Taramelli, Donatella; Romeo, Sergio; Sparatore, Anna

Rusconi, Chiara; Vaiana, Nadia; Casagrande, Manolo; Basilico, Nicoletta; Parapini, Silvia; Taramelli, Donatella; Romeo, Sergio; Sparatore, Anna.

Affiliation

Rusconi C; Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, Via Mangiagalli 25, 20133 Milan, Italy.

Bioorg Med Chem ; 20(19): 5980-5, 2012 Oct 01.

Article in En | MEDLINE | ID: mdl-22901673

Subject(s)

Aminoquinolines/chemistry; Aminoquinolines/pharmacology; Antimalarials/chemistry; Antimalarials/pharmacology; Plasmodium falciparum/drug effects; Sparteine/analogs & derivatives; Aminoquinolines/chemical synthesis; Antimalarials/chemical synthesis; Cell Line; Cell Survival/drug effects; Humans; Inhibitory Concentration 50; Lupinus/chemistry; Sparteine/chemical synthesis; Sparteine/chemistry; Sparteine/pharmacology; Stereoisomerism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasmodium falciparum / Sparteine / Aminoquinolines / Antimalarials Limits: Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2012 Type: Article Affiliation country: Italy

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