Quantitative assessment of CYP1A1*2A variations with oral carcinoma susceptibility: evidence from 1,438 cases and 2,086 controls.
Cancer Invest
; 30(8): 552-9, 2012 Oct.
Article
in En
| MEDLINE
| ID: mdl-22909097
ABSTRACT
Published evidence concerning association of CYP1A1*2A (MspI) variation with oral carcinoma risk has generated controversial results. Our previous meta-analysis in 2008 failed to reveal a marked association between CYP1A1*2A polymorphism and oral cancer susceptibility. Therefore, updated meta-analyses were conducted. Results suggested significant associations between CYP1A1*2A polymorphisms and oral carcinoma risk for the overall data, inconsistent with our previous meta-analysis. In subgroup analyses by ethnicity, variant C allele might elevate oral cancer susceptibility among Asians but not Caucasians. In conclusion, results suggest that CYP1A1*2A polymorphism might be a low-penetrant risk factor for oral carcinoma, particularly among Asians.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Mouth Neoplasms
/
Carcinoma
/
Cytochrome P-450 CYP1A1
/
Genetic Predisposition to Disease
Type of study:
Observational_studies
/
Risk_factors_studies
/
Systematic_reviews
Limits:
Humans
Language:
En
Journal:
Cancer Invest
Year:
2012
Type:
Article
Affiliation country:
China