Amyloid fibrils trigger the release of neutrophil extracellular traps (NETs), causing fibril fragmentation by NET-associated elastase.

Azevedo, Estefania P C; Guimarães-Costa, Anderson B; Torezani, Guilherme S; Braga, Carolina A; Palhano, Fernando L; Kelly, Jeffery W; Saraiva, Elvira M; Foguel, Debora

Azevedo, Estefania P C; Guimarães-Costa, Anderson B; Torezani, Guilherme S; Braga, Carolina A; Palhano, Fernando L; Kelly, Jeffery W; Saraiva, Elvira M; Foguel, Debora.

Affiliation

Azevedo EP; Instituto de Bioquímica Médica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-590, Brazil.

J Biol Chem ; 287(44): 37206-18, 2012 Oct 26.

Article in En | MEDLINE | ID: mdl-22918834

Subject(s)

Amyloid/physiology; Chromatin/metabolism; Neutrophils/pathology; Acetophenones/pharmacology; Amyloid/chemistry; Amyloid/genetics; Amyloid Neuropathies, Familial/enzymology; Amyloid Neuropathies, Familial/genetics; Amyloid Neuropathies, Familial/pathology; Amyloidosis/enzymology; Amyloidosis/metabolism; Amyloidosis/pathology; Animals; Biomarkers/metabolism; Cell Nucleus/metabolism; Cell Survival/drug effects; Chromatin/enzymology; Cricetinae; Extracellular Space/enzymology; Extracellular Space/metabolism; Hep G2 Cells; Humans; Immunoglobulin Light-chain Amyloidosis; Lung/enzymology; Lung/metabolism; Lung/pathology; Mutation, Missense; NADPH Oxidases/antagonists & inhibitors; NADPH Oxidases/metabolism; Neutrophils/enzymology; Neutrophils/metabolism; Onium Compounds/pharmacology; Pancreatic Elastase; Peptide Fragments/metabolism; Peptide Fragments/pharmacology; Peptide Fragments/physiology; Prealbumin/chemistry; Prealbumin/genetics; Prealbumin/physiology; Protein Structure, Quaternary; Proteolysis; Reactive Oxygen Species/metabolism; Skin/enzymology; Skin/metabolism; Skin/pathology; alpha-Synuclein/chemistry; alpha-Synuclein/genetics; alpha-Synuclein/physiology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chromatin / Amyloid / Neutrophils Type of study: Risk_factors_studies Language: En Journal: J Biol Chem Year: 2012 Type: Article Affiliation country: Brazil

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