Chromatin accessibility, p300, and histone acetylation define PML-RAR&#945; and AML1-ETO binding sites in acute myeloid leukemia.

Saeed, Sadia; Logie, Colin; Francoijs, Kees-Jan; Frigè, Gianmaria; Romanenghi, Mauro; Nielsen, Fiona G; Raats, Lianne; Shahhoseini, Maryam; Huynen, Martijn; Altucci, Lucia; Minucci, Saverio; Martens, Joost H A; Stunnenberg, Hendrik G

Chromatin accessibility, p300, and histone acetylation define PML-RARα and AML1-ETO binding sites in acute myeloid leukemia.

Saeed, Sadia; Logie, Colin; Francoijs, Kees-Jan; Frigè, Gianmaria; Romanenghi, Mauro; Nielsen, Fiona G; Raats, Lianne; Shahhoseini, Maryam; Huynen, Martijn; Altucci, Lucia; Minucci, Saverio; Martens, Joost H A; Stunnenberg, Hendrik G.

Affiliation

Saeed S; Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands.

Blood ; 120(15): 3058-68, 2012 Oct 11.

Article in En | MEDLINE | ID: mdl-22923494

Subject(s)

Chromatin/physiology; Core Binding Factor Alpha 2 Subunit/metabolism; E1A-Associated p300 Protein/metabolism; Gene Expression Regulation, Leukemic; Histones/metabolism; Leukemia, Myeloid, Acute/pathology; Leukemia, Promyelocytic, Acute/pathology; Oncogene Proteins, Fusion/metabolism; Acetylation; Binding Sites; Biomarkers, Tumor/genetics; Biomarkers, Tumor/metabolism; Chromatin Immunoprecipitation; Core Binding Factor Alpha 2 Subunit/genetics; DNA Methylation; E1A-Associated p300 Protein/genetics; Gene Expression Profiling; Humans; Leukemia, Myeloid, Acute/genetics; Leukemia, Myeloid, Acute/metabolism; Leukemia, Promyelocytic, Acute/genetics; Leukemia, Promyelocytic, Acute/metabolism; Oligonucleotide Array Sequence Analysis; Oncogene Proteins, Fusion/genetics; Promoter Regions, Genetic; RNA, Messenger/genetics; RUNX1 Translocation Partner 1 Protein; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chromatin / Histones / Leukemia, Myeloid, Acute / Leukemia, Promyelocytic, Acute / Gene Expression Regulation, Leukemic / Oncogene Proteins, Fusion / E1A-Associated p300 Protein / Core Binding Factor Alpha 2 Subunit Type of study: Prognostic_studies Limits: Humans Language: En Journal: Blood Year: 2012 Type: Article Affiliation country: Netherlands

Fulltext

XML

PubMed Links

Search on Google