Reduction of nitric oxide-mediated Î³-amino butyric acid release in rostral ventrolateral medulla is involved in superoxide-induced sympathoexcitation of hypertensive rats.

Shinohara, Keisuke; Hirooka, Yoshitaka; Kishi, Takuya; Sunagawa, Kenji

Shinohara, Keisuke; Hirooka, Yoshitaka; Kishi, Takuya; Sunagawa, Kenji.

Affiliation

Shinohara K; Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.

Circ J ; 76(12): 2814-21, 2012.

Article in En | MEDLINE | ID: mdl-22972304

Subject(s)

Hypertension/metabolism; Kidney/innervation; Medulla Oblongata/metabolism; Nitric Oxide/metabolism; Superoxides/metabolism; Sympathetic Nervous System/metabolism; gamma-Aminobutyric Acid/metabolism; Animals; Arterial Pressure; Bicuculline/administration & dosage; Cyclic N-Oxides/administration & dosage; Disease Models, Animal; Down-Regulation; Enzyme Inhibitors/administration & dosage; Excitatory Amino Acid Antagonists/administration & dosage; Free Radical Scavengers/administration & dosage; GABA-A Receptor Antagonists/administration & dosage; Heart Rate; Hypertension/physiopathology; Kynurenic Acid/administration & dosage; Male; Medulla Oblongata/drug effects; Medulla Oblongata/physiopathology; Microdialysis; Microinjections; NG-Nitroarginine Methyl Ester/administration & dosage; Nitric Oxide Synthase/antagonists & inhibitors; Nitric Oxide Synthase/metabolism; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Spin Labels; Sympathetic Nervous System/drug effects; Sympathetic Nervous System/physiopathology; Time Factors

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Collection: 01-internacional Database: MEDLINE Main subject: Sympathetic Nervous System / Medulla Oblongata / Superoxides / Gamma-Aminobutyric Acid / Hypertension / Kidney / Nitric Oxide Type of study: Prognostic_studies Limits: Animals Language: En Journal: Circ J Journal subject: ANGIOLOGIA / CARDIOLOGIA Year: 2012 Type: Article Affiliation country: Japan

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