Depletion of homeodomain-interacting protein kinase 3 impairs insulin secretion and glucose tolerance in mice.

Shojima, N; Hara, K; Fujita, H; Horikoshi, M; Takahashi, N; Takamoto, I; Ohsugi, M; Aburatani, H; Noda, M; Kubota, N; Yamauchi, T; Ueki, K; Kadowaki, T

Shojima, N; Hara, K; Fujita, H; Horikoshi, M; Takahashi, N; Takamoto, I; Ohsugi, M; Aburatani, H; Noda, M; Kubota, N; Yamauchi, T; Ueki, K; Kadowaki, T.

Affiliation

Shojima N; Department of Diabetes and Metabolic Disease, Graduate School of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, Japan.

Diabetologia ; 55(12): 3318-30, 2012 Dec.

Article in En | MEDLINE | ID: mdl-22983607

Subject(s)

Diabetes Mellitus, Experimental/metabolism; Diabetes Mellitus, Type 2/metabolism; Homeodomain Proteins/metabolism; Insulin-Secreting Cells/metabolism; Insulin/metabolism; Animals; Cells, Cultured; Diabetes Mellitus, Experimental/pathology; Diabetes Mellitus, Type 2/pathology; Diet, High-Fat; Female; Glucose Tolerance Test; Insulin Secretion; Insulin-Secreting Cells/pathology; Male; Mice; Mice, Knockout; Pancreas/metabolism; RNA Interference

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Homeodomain Proteins / Diabetes Mellitus, Experimental / Diabetes Mellitus, Type 2 / Insulin-Secreting Cells / Insulin Limits: Animals Language: En Journal: Diabetologia Year: 2012 Type: Article Affiliation country: Japan

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