Mice that express human interleukin-8 have increased mobilization of immature myeloid cells, which exacerbates inflammation and accelerates colon carcinogenesis.

Asfaha, Samuel; Dubeykovskiy, Alexander N; Tomita, Hiroyuki; Yang, Xiangdong; Stokes, Sarah; Shibata, Wataru; Friedman, Richard A; Ariyama, Hiroshi; Dubeykovskaya, Zinaida A; Muthupalani, Sureshkumar; Ericksen, Russell; Frucht, Harold; Fox, James G; Wang, Timothy C

Asfaha, Samuel; Dubeykovskiy, Alexander N; Tomita, Hiroyuki; Yang, Xiangdong; Stokes, Sarah; Shibata, Wataru; Friedman, Richard A; Ariyama, Hiroshi; Dubeykovskaya, Zinaida A; Muthupalani, Sureshkumar; Ericksen, Russell; Frucht, Harold; Fox, James G; Wang, Timothy C.

Affiliation

Asfaha S; Division of Digestive and Liver Diseases, Department of Medicine, Irving Cancer Research Center, Columbia University, New York, New York, USA.

Gastroenterology ; 144(1): 155-66, 2013 Jan.

Article in En | MEDLINE | ID: mdl-23041326

Subject(s)

Cell Movement/drug effects; Cell Transformation, Neoplastic/metabolism; Colitis/metabolism; Colonic Neoplasms/metabolism; Gastritis/metabolism; Interleukin-8/metabolism; Myeloid Cells/drug effects; RNA, Messenger/metabolism; Animals; Azoxymethane; Cell Line, Tumor; Colitis/chemically induced; Colonic Neoplasms/chemically induced; Colonic Neoplasms/pathology; Dendritic Cells/metabolism; Dextran Sulfate; Gastritis/microbiology; Helicobacter Infections/complications; Helicobacter felis; Humans; Interleukin-8/genetics; Interleukin-8/pharmacology; Lipopolysaccharides/pharmacology; Macrophages/metabolism; Mice; Mice, Transgenic; Myeloid Cells/metabolism; Primary Cell Culture; Tumor Burden; Up-Regulation/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA, Messenger / Cell Movement / Cell Transformation, Neoplastic / Interleukin-8 / Colitis / Colonic Neoplasms / Myeloid Cells / Gastritis Limits: Animals / Humans Language: En Journal: Gastroenterology Year: 2013 Type: Article Affiliation country: United States

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