Further characterisation of the LPS model of Parkinson's disease: a comparison of intra-nigral and intra-striatal lipopolysaccharide administration on motor function, microgliosis and nigrostriatal neurodegeneration in the rat.

Hoban, Deirdre B; Connaughton, Emer; Connaughton, Catherine; Hogan, Grace; Thornton, Chloe; Mulcahy, Padraig; Moloney, Teresa C; Dowd, Eilis

Hoban, Deirdre B; Connaughton, Emer; Connaughton, Catherine; Hogan, Grace; Thornton, Chloe; Mulcahy, Padraig; Moloney, Teresa C; Dowd, Eilis.

Affiliation

Hoban DB; The Department of Pharmacology & Therapeutics, School of Medicine, National University of Ireland, Galway, Ireland.

Brain Behav Immun ; 27(1): 91-100, 2013 Jan.

Article in En | MEDLINE | ID: mdl-23044176

Subject(s)

Behavior, Animal/drug effects; Corpus Striatum; Gliosis; Lipopolysaccharides/pharmacology; Motor Activity/drug effects; Parkinson Disease/immunology; Substantia Nigra; Animals; CD11b Antigen/drug effects; CD11b Antigen/metabolism; Corpus Striatum/drug effects; Corpus Striatum/metabolism; Corpus Striatum/pathology; Disease Models, Animal; Gliosis/chemically induced; Gliosis/pathology; Immunohistochemistry; Male; Motor Skills/drug effects; Rats; Rats, Sprague-Dawley; Substantia Nigra/drug effects; Substantia Nigra/metabolism; Substantia Nigra/pathology; Tyrosine 3-Monooxygenase/drug effects; Tyrosine 3-Monooxygenase/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Behavior, Animal / Substantia Nigra / Lipopolysaccharides / Corpus Striatum / Gliosis / Motor Activity Limits: Animals Language: En Journal: Brain Behav Immun Journal subject: ALERGIA E IMUNOLOGIA / CEREBRO / PSICOFISIOLOGIA Year: 2013 Type: Article Affiliation country: Ireland

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