Epileptiform activity and cognitive deficits in SNAP-25(+/-) mice are normalized by antiepileptic drugs.

Corradini, Irene; Donzelli, Andrea; Antonucci, Flavia; Welzl, Hans; Loos, Maarten; Martucci, Roberta; De Astis, Silvia; Pattini, Linda; Inverardi, Francesca; Wolfer, David; Caleo, Matteo; Bozzi, Yuri; Verderio, Claudia; Frassoni, Carolina; Braida, Daniela; Clerici, Mario; Lipp, Hans-Peter; Sala, Mariaelvina; Matteoli, Michela

Corradini, Irene; Donzelli, Andrea; Antonucci, Flavia; Welzl, Hans; Loos, Maarten; Martucci, Roberta; De Astis, Silvia; Pattini, Linda; Inverardi, Francesca; Wolfer, David; Caleo, Matteo; Bozzi, Yuri; Verderio, Claudia; Frassoni, Carolina; Braida, Daniela; Clerici, Mario; Lipp, Hans-Peter; Sala, Mariaelvina; Matteoli, Michela.

Affiliation

Corradini I; Dipartimento di Biotecnologie Mediche e Medicina Traslazionale, Università degli Studi di Milano, 20129 Milan, Italy.

Cereb Cortex ; 24(2): 364-76, 2014 Feb.

Article in En | MEDLINE | ID: mdl-23064108

Subject(s)

Anticonvulsants/therapeutic use; Cognition Disorders/drug therapy; Epilepsy/drug therapy; Synaptosomal-Associated Protein 25/metabolism; Animals; Association Learning/drug effects; Association Learning/physiology; Brain/drug effects; Brain/pathology; Brain/physiopathology; Carbamazepine/therapeutic use; Cognition Disorders/pathology; Cognition Disorders/physiopathology; Epilepsy/pathology; Epilepsy/physiopathology; Ethosuximide/therapeutic use; Hyperkinesis/drug therapy; Hyperkinesis/pathology; Hyperkinesis/physiopathology; Kainic Acid; Male; Memory Disorders/drug therapy; Memory Disorders/pathology; Memory Disorders/physiopathology; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurons/drug effects; Neurons/physiology; Nimodipine/therapeutic use; Seizures/chemically induced; Seizures/physiopathology; Synaptosomal-Associated Protein 25/genetics; Valproic Acid/therapeutic use

Key words

SNAP-25; epilepsy; memory; valproate

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cognition Disorders / Epilepsy / Synaptosomal-Associated Protein 25 / Anticonvulsants Limits: Animals Language: En Journal: Cereb Cortex Journal subject: CEREBRO Year: 2014 Type: Article Affiliation country: Italy

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