Structural diversity of new C13-polyketides produced by Chaetomium mollipilium cultivated in the presence of a NAD(+)-dependent histone deacetylase inhibitor.

Asai, Teigo; Morita, Shuntaro; Shirata, Naoki; Taniguchi, Tohru; Monde, Kenji; Sakurai, Hiroaki; Ozeki, Tomoji; Oshima, Yoshiteru

Asai, Teigo; Morita, Shuntaro; Shirata, Naoki; Taniguchi, Tohru; Monde, Kenji; Sakurai, Hiroaki; Ozeki, Tomoji; Oshima, Yoshiteru.

Affiliation

Asai T; Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba-yama, Aoba-ku, Sendai 980-8578, Japan. tasai@m.tohoku.ac.jp

Org Lett ; 14(21): 5456-9, 2012 Nov 02.

Article in En | MEDLINE | ID: mdl-23083076

Subject(s)

Antineoplastic Agents, Phytogenic/isolation & purification; Antineoplastic Agents, Phytogenic/pharmacology; Chaetomium/chemistry; Group III Histone Deacetylases/metabolism; Histone Deacetylase Inhibitors/pharmacology; Polyketides/isolation & purification; Polyketides/pharmacology; Antineoplastic Agents, Phytogenic/chemistry; Crystallography, X-Ray; HCT116 Cells; Histone Deacetylase Inhibitors/chemistry; Humans; Molecular Structure; NAD/metabolism; Niacinamide/metabolism; Nuclear Magnetic Resonance, Biomolecular; Polyketides/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chaetomium / Group III Histone Deacetylases / Histone Deacetylase Inhibitors / Polyketides / Antineoplastic Agents, Phytogenic Limits: Humans Language: En Journal: Org Lett Journal subject: BIOQUIMICA Year: 2012 Type: Article Affiliation country: Japan

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