Effects of ketoconazole treatment on the pharmacokinetics of safinamide and its plasma metabolites in healthy adult subjects.

Krösser, Sonja; Marquet, Anne; Gallemann, Dieter; Wolna, Peter; Fauchoux, Nicolas; Hermann, Robert; Johne, Andreas

Krösser, Sonja; Marquet, Anne; Gallemann, Dieter; Wolna, Peter; Fauchoux, Nicolas; Hermann, Robert; Johne, Andreas.

Affiliation

Krösser S; Department of Exploratory Medicine, Merck KGaA, D-64293 Darmstadt, Germany. sonja.kroesser@merckgroup.com

Biopharm Drug Dispos ; 33(9): 550-9, 2012 Dec.

Article in En | MEDLINE | ID: mdl-23097240

Subject(s)

Alanine/analogs & derivatives; Antiparkinson Agents/pharmacokinetics; Benzylamines/pharmacokinetics; Cytochrome P-450 CYP3A Inhibitors; Enzyme Inhibitors/administration & dosage; Ketoconazole/administration & dosage; Adult; Alanine/administration & dosage; Alanine/blood; Alanine/pharmacokinetics; Antifungal Agents/administration & dosage; Antiparkinson Agents/administration & dosage; Antiparkinson Agents/blood; Benzylamines/administration & dosage; Benzylamines/blood; Cross-Over Studies; Cytochrome P-450 CYP3A/metabolism; Drug Interactions; Female; Humans; Male; Young Adult

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzylamines / Alanine / Enzyme Inhibitors / Cytochrome P-450 CYP3A Inhibitors / Ketoconazole / Antiparkinson Agents Type of study: Clinical_trials Limits: Adult / Female / Humans / Male Language: En Journal: Biopharm Drug Dispos Year: 2012 Type: Article Affiliation country: Germany

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