Tumor-associated macrophages promote invasion while retaining Fc-dependent anti-tumor function.

Grugan, Katharine D; McCabe, Francis L; Kinder, Michelle; Greenplate, Allison R; Harman, Benjamin C; Ekert, Jason E; van Rooijen, Nico; Anderson, G Mark; Nemeth, Jeffrey A; Strohl, William R; Jordan, Robert E; Brezski, Randall J

Grugan, Katharine D; McCabe, Francis L; Kinder, Michelle; Greenplate, Allison R; Harman, Benjamin C; Ekert, Jason E; van Rooijen, Nico; Anderson, G Mark; Nemeth, Jeffrey A; Strohl, William R; Jordan, Robert E; Brezski, Randall J.

Affiliation

Grugan KD; Biologics Research, Janssen Research & Development, Radnor, PA 19087, USA. kgrugan1@its.jnj.com

J Immunol ; 189(11): 5457-66, 2012 Dec 01.

Article in En | MEDLINE | ID: mdl-23105143

Subject(s)

Antibodies, Neoplasm/immunology; Antigens, Neoplasm/immunology; Breast Neoplasms/immunology; Macrophages/immunology; Phagocytosis; Receptors, IgG/immunology; Animals; Breast Neoplasms/pathology; CD11b Antigen/immunology; Cell Movement/drug effects; Cell Proliferation; Culture Media, Conditioned/pharmacology; Disease Progression; Female; Humans; Immunophenotyping; Lipopolysaccharide Receptors/immunology; Macrophage Colony-Stimulating Factor/immunology; Macrophages/drug effects; Macrophages/pathology; Mice; Mice, SCID; Neoplasm Invasiveness/immunology; Neoplasm Transplantation; Primary Cell Culture

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phagocytosis / Breast Neoplasms / Receptors, IgG / Macrophages / Antibodies, Neoplasm / Antigens, Neoplasm Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Female / Humans Language: En Journal: J Immunol Year: 2012 Type: Article Affiliation country: United States

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