Alcohol-induced one-carbon metabolism impairment promotes dysfunction of DNA base excision repair in adult brain.

Fowler, Anna-Kate; Hewetson, Aveline; Agrawal, Rajiv G; Dagda, Marisela; Dagda, Raul; Moaddel, Ruin; Balbo, Silvia; Sanghvi, Mitesh; Chen, Yukun; Hogue, Ryan J; Bergeson, Susan E; Henderson, George I; Kruman, Inna I

Fowler, Anna-Kate; Hewetson, Aveline; Agrawal, Rajiv G; Dagda, Marisela; Dagda, Raul; Moaddel, Ruin; Balbo, Silvia; Sanghvi, Mitesh; Chen, Yukun; Hogue, Ryan J; Bergeson, Susan E; Henderson, George I; Kruman, Inna I.

Affiliation

Fowler AK; Department of Pharmacology and Neuroscience, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA.

J Biol Chem ; 287(52): 43533-42, 2012 Dec 21.

Article in En | MEDLINE | ID: mdl-23118224

Subject(s)

Alcohol Drinking/adverse effects; Central Nervous System Depressants/adverse effects; DNA Damage/drug effects; DNA Repair/drug effects; Ethanol/adverse effects; Methylenetetrahydrofolate Reductase (NADPH2)/metabolism; Adult; Alcohol Drinking/metabolism; Animals; Carbon/metabolism; Central Nervous System Depressants/pharmacology; DNA Repair/genetics; Ethanol/pharmacology; Genomic Instability/drug effects; Genomic Instability/genetics; Homocysteine/genetics; Homocysteine/metabolism; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2)/genetics; Mice; Mice, Mutant Strains; Mutation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA Damage / Alcohol Drinking / Central Nervous System Depressants / Methylenetetrahydrofolate Reductase (NADPH2) / Ethanol / DNA Repair Limits: Adult / Animals / Humans / Male Language: En Journal: J Biol Chem Year: 2012 Type: Article Affiliation country: United States

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