Rapid nucleotide exchange renders Asp-11 mutant actins resistant to depolymerizing activity of cofilin, leading to dominant toxicity in vivo.

Umeki, Nobuhisa; Nakajima, Jun; Noguchi, Taro Q P; Tokuraku, Kiyotaka; Nagasaki, Akira; Ito, Kohji; Hirose, Keiko; Uyeda, Taro Q P

Umeki, Nobuhisa; Nakajima, Jun; Noguchi, Taro Q P; Tokuraku, Kiyotaka; Nagasaki, Akira; Ito, Kohji; Hirose, Keiko; Uyeda, Taro Q P.

Affiliation

Umeki N; Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki 305-8562, Japan.

J Biol Chem ; 288(3): 1739-49, 2013 Jan 18.

Article in En | MEDLINE | ID: mdl-23212920

Subject(s)

Actin Depolymerizing Factors/metabolism; Actins/metabolism; Aspartic Acid/metabolism; Dictyostelium/metabolism; Nucleotides/metabolism; Protozoan Proteins/metabolism; Actin Cytoskeleton/chemistry; Actin Cytoskeleton/metabolism; Actin Depolymerizing Factors/chemistry; Actin Depolymerizing Factors/genetics; Actins/chemistry; Actins/genetics; Adenosine Triphosphate/chemistry; Adenosine Triphosphate/metabolism; Aspartic Acid/chemistry; Binding Sites; Conserved Sequence; Dictyostelium/genetics; Humans; Kinetics; Models, Molecular; Mutation; Nucleotides/genetics; Plasmids; Polymerization; Protein Binding; Protein Stability; Protozoan Proteins/chemistry; Protozoan Proteins/genetics; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae/metabolism; Transfection

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protozoan Proteins / Actins / Aspartic Acid / Dictyostelium / Actin Depolymerizing Factors / Nucleotides Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Biol Chem Year: 2013 Type: Article Affiliation country: Japan

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