Cathepsin L stimulates autophagy and inhibits apoptosis of ox-LDL-induced endothelial cells: potential role in atherosclerosis.

Wei, Dang-Heng; Jia, Xiao-Ying; Liu, Yang-Hui; Guo, Feng-Xia; Tang, Zhi-Han; Li, Xiao-Hong; Wang, Zuo; Liu, Lu-Shan; Wang, Gui-Xue; Jian, Zhi-Sheng; Ruan, Chang-Geng

Wei, Dang-Heng; Jia, Xiao-Ying; Liu, Yang-Hui; Guo, Feng-Xia; Tang, Zhi-Han; Li, Xiao-Hong; Wang, Zuo; Liu, Lu-Shan; Wang, Gui-Xue; Jian, Zhi-Sheng; Ruan, Chang-Geng.

Affiliation

Wei DH; Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, University of South China, Hengyang 421001, P.R. China. weizhonghua99@126.com

Int J Mol Med ; 31(2): 400-6, 2013 Feb.

Article in En | MEDLINE | ID: mdl-23229094

Subject(s)

Cathepsin L/metabolism; Endothelial Cells/enzymology; Lipoproteins, LDL/metabolism; Antigens, CD/metabolism; Apoptosis/drug effects; Atherosclerosis/drug therapy; Atherosclerosis/enzymology; Atherosclerosis/genetics; Atherosclerosis/pathology; Autophagy/drug effects; Cadherins/metabolism; Cathepsin L/antagonists & inhibitors; Cathepsin L/genetics; Endothelial Cells/metabolism; Endothelial Cells/pathology; Enzyme Activation; Human Umbilical Vein Endothelial Cells; Humans; Permeability/drug effects; Protease Inhibitors/pharmacology; RNA, Messenger/genetics; Up-Regulation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Endothelial Cells / Cathepsin L / Lipoproteins, LDL Limits: Humans Language: En Journal: Int J Mol Med Journal subject: BIOLOGIA MOLECULAR / GENETICA MEDICA Year: 2013 Type: Article

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