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Evaluating the role of curcum powder as a protective factor against bladder cancer--an experimental study.
El-Mesallamy, Hala; Salman, Tarek M; Ashmawey, Abeer M; Osama, Nada.
Affiliation
  • El-Mesallamy H; Biochemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. hala_elmosalamy@yahoo.com
Asian Pac J Cancer Prev ; 13(10): 5287-90, 2012.
Article in En | MEDLINE | ID: mdl-23244150
ABSTRACT
Throughout human history, plant products have been used for many purposes including as medicines. Herbal products and spices can be used as preventive agents against cancer due to their antimicrobial, antioxidant and antitumorigenic properties. This study was designed to evaluate the potential protective effect of curcum in rats administered nitrosamine precursors; dibutylamine (DBA) and sodium nitrate (NaNO3); and infected with Escherichia coli (E. coli) and also to monitor changes in nuclear factor the Kappa B p65 (NF-κB p56) pathway and its downstream products, Bcl-2 and interleukin-6 (IL-6), in parallel with nitrosamine precursors, E. coli and curcum treatment. Rats were divided into three groups (n=25 each; except of control group, n+20). Group I a normal control group, group II administered DBA/NaNO3 in drinking water and infected with E. coli and group III was administered DBA/NaNO3 in drinking water, infected with E. coli and receiving standard diet containing 1% curcum powder. Histopathological examination reflected that the curcum treated group featured a lower incidence of urinary bladder lesions,and lower levels of NF-κB, Bcl-2 and IL-6, than the group receiving nitrosamine precursor and infected with E. coli. These findings suggested that curcum may have a protective role during the process of bladder carcinogenesis by inhibiting the NF-κB pathway and its downstream products.
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Collection: 01-internacional Database: MEDLINE Main subject: Urinary Bladder / Urinary Bladder Neoplasms / Curcuma / Diet / Escherichia coli Type of study: Etiology_studies Limits: Animals Language: En Journal: Asian Pac J Cancer Prev Journal subject: NEOPLASIAS Year: 2012 Type: Article Affiliation country: Egypt
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Collection: 01-internacional Database: MEDLINE Main subject: Urinary Bladder / Urinary Bladder Neoplasms / Curcuma / Diet / Escherichia coli Type of study: Etiology_studies Limits: Animals Language: En Journal: Asian Pac J Cancer Prev Journal subject: NEOPLASIAS Year: 2012 Type: Article Affiliation country: Egypt