HCV IRES manipulates the ribosome to promote the switch from translation initiation to elongation.

Filbin, Megan E; Vollmar, Breanna S; Shi, Dan; Gonen, Tamir; Kieft, Jeffrey S

Filbin, Megan E; Vollmar, Breanna S; Shi, Dan; Gonen, Tamir; Kieft, Jeffrey S.

Affiliation

Filbin ME; Department of Biochemistry and Molecular Genetics, University of Colorado Denver School of Medicine, Aurora, Colorado, USA.

Nat Struct Mol Biol ; 20(2): 150-8, 2013 Feb.

Article in En | MEDLINE | ID: mdl-23262488

Subject(s)

Hepacivirus/physiology; Models, Molecular; Peptide Chain Elongation, Translational/physiology; Peptide Chain Initiation, Translational/physiology; RNA, Viral/metabolism; Ribosomes/metabolism; Virus Replication/physiology; Animals; Cloning, Molecular; Cryoelectron Microscopy; DNA Primers/genetics; Hepacivirus/metabolism; Humans; Luciferases; Magnetic Resonance Spectroscopy; Microscopy, Electron; Mutation/genetics; Nucleic Acid Conformation; Plasmids/genetics; RNA, Viral/genetics; Rabbits; Ribosome Subunits, Small, Eukaryotic/chemistry; Ribosome Subunits, Small, Eukaryotic/metabolism; Ribosomes/genetics; Virus Replication/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Chain Elongation, Translational / Peptide Chain Initiation, Translational / Ribosomes / Virus Replication / RNA, Viral / Models, Molecular / Hepacivirus Limits: Animals / Humans Language: En Journal: Nat Struct Mol Biol Journal subject: BIOLOGIA MOLECULAR Year: 2013 Type: Article Affiliation country: United States

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