Structure activity relationship studies of tricyclic bispyran sulfone Î³-secretase inhibitors.

Wu, Wen-Lian; Asberom, Theodros; Bara, Thomas; Bennett, Chad; Burnett, Duane A; Clader, John; Domalski, Martin; Greenlee, William J; Josien, Hubert; McBriar, Mark; Rajagopalan, Murali; Vicarel, Monica; Xu, Ruo; Hyde, Lynn A; Del Vecchio, Robert A; Cohen-Williams, Mary E; Song, Lixin; Lee, Julie; Terracina, Giuseppe; Zhang, Qi; Nomeir, Amin; Parker, Eric M; Zhang, Lili

Wu, Wen-Lian; Asberom, Theodros; Bara, Thomas; Bennett, Chad; Burnett, Duane A; Clader, John; Domalski, Martin; Greenlee, William J; Josien, Hubert; McBriar, Mark; Rajagopalan, Murali; Vicarel, Monica; Xu, Ruo; Hyde, Lynn A; Del Vecchio, Robert A; Cohen-Williams, Mary E; Song, Lixin; Lee, Julie; Terracina, Giuseppe; Zhang, Qi; Nomeir, Amin; Parker, Eric M; Zhang, Lili.

Affiliation

Wu WL; Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA. wen-lian.wu@merck.com

Bioorg Med Chem Lett ; 23(3): 844-9, 2013 Feb 01.

Article in En | MEDLINE | ID: mdl-23265892

Subject(s)

Amyloid Precursor Protein Secretases/antagonists & inhibitors; Benzopyrans/chemical synthesis; Benzopyrans/pharmacology; Enzyme Inhibitors/chemistry; Enzyme Inhibitors/pharmacology; Sulfones/chemical synthesis; Sulfones/pharmacology; Benzopyrans/chemistry; Cyclization; Enzyme Activation/drug effects; Humans; Inhibitory Concentration 50; Molecular Structure; Pyrans/chemical synthesis; Pyrans/chemistry; Pyrans/pharmacology; Structure-Activity Relationship; Sulfones/chemistry

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfones / Benzopyrans / Enzyme Inhibitors / Amyloid Precursor Protein Secretases Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2013 Type: Article Affiliation country: United States

Fulltext

XML

PubMed Links

Search on Google