One-year progression of moderate asymptomatic carotid stenosis predicts the risk of vascular events.
Stroke
; 44(3): 792-4, 2013 Mar.
Article
in En
| MEDLINE
| ID: mdl-23287778
ABSTRACT
BACKGROUND AND PURPOSE:
This study aimed at evaluating whether ultrasound monitoring of moderate asymptomatic carotid stenosis may help in identifying subjects at high risk for vascular events.METHODS:
We included 523 subjects with unilateral asymptomatic carotid stenosis of 50% to 69%. Follow-up carotid ultrasound was performed within 12 months from inclusion to detect the frequency and degree of stenosis progression. Subjects were prospectively evaluated for a median period of 42 months (interquartile range, 38-45) after a second ultrasound evaluation. Outcome measures were any stroke and transient ischemic attack, myocardial infarction, and death.RESULTS:
Carotid stenosis progression was associated with the occurrence of vascular events (hazard ratio, 21.57; 95% confidence interval, 11.81-39.39; P<0.001). During follow-up, 96.7% of subjects without progressive carotid stenosis remained free from vascular events. Among patients with progressive stenosis, 53.7% experienced a vascular event and 27.1% experienced an ipsilateral stroke.CONCLUSIONS:
One-year moderate asymptomatic carotid stenosis progression is related to higher risk of vascular events, including ipsilateral stroke.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ischemic Attack, Transient
/
Carotid Stenosis
/
Disease Progression
/
Stroke
/
Myocardial Infarction
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
En
Journal:
Stroke
Year:
2013
Type:
Article
Affiliation country:
Italy