Sickle hemoglobin disturbs normal coupling among erythrocyte O2 content, glycolysis, and antioxidant capacity.

Rogers, Stephen C; Ross, Jerlinda G C; d'Avignon, Andre; Gibbons, Lindsey B; Gazit, Vered; Hassan, Mojibade N; McLaughlin, Dylan; Griffin, Sherraine; Neumayr, Tara; Debaun, Malcolm; DeBaun, Michael R; Doctor, Allan

Rogers, Stephen C; Ross, Jerlinda G C; d'Avignon, Andre; Gibbons, Lindsey B; Gazit, Vered; Hassan, Mojibade N; McLaughlin, Dylan; Griffin, Sherraine; Neumayr, Tara; Debaun, Malcolm; DeBaun, Michael R; Doctor, Allan.

Affiliation

Rogers SC; Division of Critical Care Medicine, Department of Pediatrics, Washington University School of Medicine, 1 Children's Pl, St Louis, MO 63110, USA.

Blood ; 121(9): 1651-62, 2013 Feb 28.

Article in En | MEDLINE | ID: mdl-23297128

Subject(s)

Antioxidants/metabolism; Erythrocytes/metabolism; Glycolysis; Hemoglobin, Sickle/physiology; Oxygen/metabolism; Adolescent; Adult; Case-Control Studies; Child; Child, Preschool; Erythrocytes/drug effects; Glycolysis/drug effects; Glycolysis/physiology; Hemoglobin, Sickle/adverse effects; Hemoglobin, Sickle/pharmacology; Humans; Models, Biological; Oxidation-Reduction/drug effects; Oxidative Stress/drug effects; Oxidative Stress/physiology; Young Adult

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxygen / Hemoglobin, Sickle / Erythrocytes / Glycolysis / Antioxidants Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adolescent / Adult / Child / Child, preschool / Humans Language: En Journal: Blood Year: 2013 Type: Article Affiliation country: United States

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