SCRAPPER regulates the thresholds of long-term potentiation/depression, the bidirectional synaptic plasticity in hippocampal CA3-CA1 synapses.
Neural Plast
; 2012: 352829, 2012.
Article
in En
| MEDLINE
| ID: mdl-23316391
ABSTRACT
SCRAPPER, which is an F-box protein encoded by FBXL20, regulates the frequency of the miniature excitatory synaptic current through the ubiquitination of Rab3-interacting molecule 1. Here, we recorded the induction of long-term potentiation/depression (LTP/LTD) in CA3-CA1 synapses in E3 ubiquitin ligase SCRAPPER-deficient hippocampal slices. Compared to wild-type mice, Scrapper-knockout mice exhibited LTDs with smaller magnitudes after induction with low-frequency stimulation and LTPs with larger magnitudes after induction with tetanus stimulation. These findings suggest that SCRAPPER regulates the threshold of bidirectional synaptic plasticity and, therefore, metaplasticity.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Synapses
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Long-Term Potentiation
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Long-Term Synaptic Depression
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Ubiquitin-Protein Ligases
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Hippocampus
Limits:
Animals
Language:
En
Journal:
Neural Plast
Journal subject:
NEUROLOGIA
Year:
2012
Type:
Article
Affiliation country:
Japan