Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders.

Song, Ruisheng; Peng, Wei; Zhang, Yan; Lv, Fengxiang; Wu, Hong-Kun; Guo, Jiaojiao; Cao, Yongxing; Pi, Yanbin; Zhang, Xin; Jin, Li; Zhang, Mao; Jiang, Peng; Liu, Fenghua; Meng, Shaoshuai; Zhang, Xiuqin; Jiang, Ping; Cao, Chun-Mei; Xiao, Rui-Ping

Song, Ruisheng; Peng, Wei; Zhang, Yan; Lv, Fengxiang; Wu, Hong-Kun; Guo, Jiaojiao; Cao, Yongxing; Pi, Yanbin; Zhang, Xin; Jin, Li; Zhang, Mao; Jiang, Peng; Liu, Fenghua; Meng, Shaoshuai; Zhang, Xiuqin; Jiang, Ping; Cao, Chun-Mei; Xiao, Rui-Ping.

Affiliation

Song R; Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University, Beijing 100871, China.

Nature ; 494(7437): 375-9, 2013 Feb 21.

Article in En | MEDLINE | ID: mdl-23354051

Subject(s)

Carrier Proteins/metabolism; Insulin Resistance/physiology; Insulin; Metabolic Syndrome/metabolism; Ubiquitin-Protein Ligases/metabolism; Animals; Carrier Proteins/genetics; Diabetes Mellitus, Type 2; Diet, High-Fat; Dyslipidemias/metabolism; Gene Deletion; Hypertension/metabolism; Insulin/metabolism; Insulin Receptor Substrate Proteins/metabolism; Insulin Resistance/genetics; Male; Membrane Proteins; Metabolic Syndrome/enzymology; Metabolic Syndrome/genetics; Metabolic Syndrome/prevention & control; Mice; Obesity/chemically induced; Obesity/metabolism; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Insulin/metabolism; Signal Transduction; Ubiquitination

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Insulin Resistance / Carrier Proteins / Metabolic Syndrome / Ubiquitin-Protein Ligases / Insulin Type of study: Prognostic_studies Limits: Animals Language: En Journal: Nature Year: 2013 Type: Article Affiliation country: China

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