[Photodynamic diagnosis and laser biospectroscopy as an intraoperative guidance in neurosurgery].

Goriainov, S A; Potapov, A A; Gol'bin, D A; Zelenkov, P V; Kobiakov, G L; Gavrilov, A G; Okhlopkov, V A; Shukhrai, V A; Shelesko, E V; Zhukov, V Iu; Loshchenov, V B; Savel'eva, T A

Goriainov, S A; Potapov, A A; Gol'bin, D A; Zelenkov, P V; Kobiakov, G L; Gavrilov, A G; Okhlopkov, V A; Shukhrai, V A; Shelesko, E V; Zhukov, V Iu; Loshchenov, V B; Savel'eva, T A.

Zh Vopr Neirokhir Im N N Burdenko ; 76(6): 57-65; discussion 65, 2012.

Article in Ru | MEDLINE | ID: mdl-23379185

ABSTRACT

ABSTRACT

Different techniques are used today in neurosurgery for intraoperative navigation, including metabolic guidance using 5-aminolevulinic acid (5-ALA). The article focuses on history of intraoperative photodynamic diagnosis (PDD), mechanisms of 5-ALA action, possibilities of its application in different areas of neurosurgery. In addition to visual assessment of fluorescence, laser biospectroscopy significantly increases the diagnostic value of PDD. Laser biospectroanalysis is described in details, wide perspectives of its application in neurosurgery are demonstrated.

Subject(s)

Aminolevulinic Acid/pharmacology; Lasers; Neurosurgical Procedures/instrumentation; Neurosurgical Procedures/methods; Optical Imaging; Photosensitizing Agents/pharmacology; Humans; Optical Imaging/instrumentation; Optical Imaging/methods; Spectrometry, Fluorescence/instrumentation; Spectrometry, Fluorescence/methods

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Collection: 01-internacional Database: MEDLINE Main subject: Photosensitizing Agents / Neurosurgical Procedures / Optical Imaging / Aminolevulinic Acid / Lasers Type of study: Diagnostic_studies / Guideline Limits: Humans Language: Ru Journal: Zh Vopr Neirokhir Im N N Burdenko Year: 2012 Type: Article

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