KRAS gene amplification in colorectal cancer and impact on response to EGFR-targeted therapy.

Valtorta, Emanuele; Misale, Sandra; Sartore-Bianchi, Andrea; Nagtegaal, Iris D; Paraf, François; Lauricella, Calogero; Dimartino, Valentina; Hobor, Sebastijan; Jacobs, Bart; Ercolani, Cristiana; Lamba, Simona; Scala, Elisa; Veronese, Silvio; Laurent-Puig, Pierre; Siena, Salvatore; Tejpar, Sabine; Mottolese, Marcella; Punt, Cornelis J A; Gambacorta, Marcello; Bardelli, Alberto; Di Nicolantonio, Federica

Valtorta, Emanuele; Misale, Sandra; Sartore-Bianchi, Andrea; Nagtegaal, Iris D; Paraf, François; Lauricella, Calogero; Dimartino, Valentina; Hobor, Sebastijan; Jacobs, Bart; Ercolani, Cristiana; Lamba, Simona; Scala, Elisa; Veronese, Silvio; Laurent-Puig, Pierre; Siena, Salvatore; Tejpar, Sabine; Mottolese, Marcella; Punt, Cornelis J A; Gambacorta, Marcello; Bardelli, Alberto; Di Nicolantonio, Federica.

Affiliation

Valtorta E; Division of Pathology, Ospedale Niguarda Ca' Granda, Piazza Ospedale Maggiore 3, Milano, Italy.

Int J Cancer ; 133(5): 1259-65, 2013 Sep 01.

Article in En | MEDLINE | ID: mdl-23404247

Subject(s)

Colorectal Neoplasms/genetics; ErbB Receptors/antagonists & inhibitors; Gene Amplification; Proto-Oncogene Proteins/genetics; ras Proteins/genetics; Cell Line, Tumor; Colorectal Neoplasms/drug therapy; Humans; Proto-Oncogene Proteins p21(ras); Retrospective Studies

Key words

EGFR; EGFR therapy; KRAS; KRAS amplification; biomarkers; cetuximab; colorectal cancer; panitumumab; resistance

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / Gene Amplification / Proto-Oncogene Proteins / Ras Proteins / ErbB Receptors Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Int J Cancer Year: 2013 Type: Article Affiliation country: Italy

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