Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides.

Wefers, Benedikt; Meyer, Melanie; Ortiz, Oskar; Hrabé de Angelis, Martin; Hansen, Jens; Wurst, Wolfgang; Kühn, Ralf

Wefers, Benedikt; Meyer, Melanie; Ortiz, Oskar; Hrabé de Angelis, Martin; Hansen, Jens; Wurst, Wolfgang; Kühn, Ralf.

Affiliation

Wefers B; Institute of Developmental Genetics, Helmholtz Zentrum München, 85764 Munich, Germany.

Proc Natl Acad Sci U S A ; 110(10): 3782-7, 2013 Mar 05.

Article in En | MEDLINE | ID: mdl-23426636

Subject(s)

Disease Models, Animal; Genetic Diseases, Inborn/genetics; Germ-Line Mutation; Oligodeoxyribonucleotides/administration & dosage; Oligodeoxyribonucleotides/genetics; Amino Acid Sequence; Animals; Base Sequence; Cleavage Stage, Ovum; Deoxyribonucleases/administration & dosage; Deoxyribonucleases/genetics; Female; Genetic Techniques; Genetic Vectors; HEK293 Cells; Humans; Male; Mice; Mice, Transgenic; Microinjections; Molecular Sequence Data; Mutagenesis; Mutation, Missense; Pregnancy; Sequence Homology, Nucleic Acid; rab GTP-Binding Proteins/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligodeoxyribonucleotides / Germ-Line Mutation / Disease Models, Animal / Genetic Diseases, Inborn Limits: Animals / Female / Humans / Male / Pregnancy Language: En Journal: Proc Natl Acad Sci U S A Year: 2013 Type: Article Affiliation country: Germany

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