A rationally designed A34R mutant oncolytic poxvirus: improved efficacy in peritoneal carcinomatosis.

Thirunavukarasu, Pragatheeshwar; Sathaiah, Magesh; Gorry, Michael C; O'Malley, Mark E; Ravindranathan, Roshni; Austin, Frances; Thorne, Steven H; Guo, Zong Sheng; Bartlett, David L

Thirunavukarasu, Pragatheeshwar; Sathaiah, Magesh; Gorry, Michael C; O'Malley, Mark E; Ravindranathan, Roshni; Austin, Frances; Thorne, Steven H; Guo, Zong Sheng; Bartlett, David L.

Affiliation

Thirunavukarasu P; Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

Mol Ther ; 21(5): 1024-33, 2013 May.

Article in En | MEDLINE | ID: mdl-23439499

Subject(s)

Genetic Vectors/physiology; Mutation; Oncolytic Viruses/physiology; Poxviridae/physiology; Viral Proteins/genetics; Animals; Carcinoma/immunology; Carcinoma/mortality; Carcinoma/therapy; Cell Line, Tumor; Cytopathogenic Effect, Viral; Disease Models, Animal; Female; Gene Transfer Techniques; Genetic Vectors/administration & dosage; Humans; Mice; Oncolytic Virotherapy; Peritoneal Neoplasms/immunology; Peritoneal Neoplasms/mortality; Peritoneal Neoplasms/therapy; Poxviridae Infections/immunology; Poxviridae Infections/virology; Vaccinia virus/physiology; Virus Replication

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Poxviridae / Viral Proteins / Oncolytic Viruses / Genetic Vectors / Mutation Limits: Animals / Female / Humans Language: En Journal: Mol Ther Journal subject: BIOLOGIA MOLECULAR / TERAPEUTICA Year: 2013 Type: Article Affiliation country: United States

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