Mechanisms of ceramide-induced COX-2-dependent apoptosis in human ovarian cancer OVCAR-3 cells partially overlapped with resveratrol.

Lin, Hung-Yun; Delmas, Dominique; Vang, Ole; Hsieh, Tze-Chen; Lin, Sharon; Cheng, Guei-Yun; Chiang, Hsiao-Ling; Chen, Chiao En; Tang, Heng-Yuan; Crawford, Dana R; Whang-Peng, Jacqueline; Hwang, Jaulang; Liu, Leroy F; Wu, Joseph M

Lin, Hung-Yun; Delmas, Dominique; Vang, Ole; Hsieh, Tze-Chen; Lin, Sharon; Cheng, Guei-Yun; Chiang, Hsiao-Ling; Chen, Chiao En; Tang, Heng-Yuan; Crawford, Dana R; Whang-Peng, Jacqueline; Hwang, Jaulang; Liu, Leroy F; Wu, Joseph M.

Affiliation

Lin HY; Institute of Cancer Biology and Drug Discovery, Taipei Medical University, Taipei, Taiwan. linhy@tmu.edu.tw

J Cell Biochem ; 114(8): 1940-54, 2013 Aug.

Article in En | MEDLINE | ID: mdl-23495037

Subject(s)

Anti-Inflammatory Agents, Non-Steroidal/pharmacology; Apoptosis/drug effects; Ceramides/pharmacology; Cyclooxygenase 2/metabolism; Gene Expression Regulation, Enzymologic/drug effects; Gene Expression Regulation, Neoplastic/drug effects; Ovarian Neoplasms/metabolism; Stilbenes/pharmacology; Apoptosis/genetics; Caspase 3/genetics; Caspase 3/metabolism; Caspase 7/genetics; Caspase 7/metabolism; Cell Line, Tumor; Ceramides/genetics; Ceramides/metabolism; Cyclooxygenase 2/genetics; Female; Gene Expression Regulation, Enzymologic/genetics; Gene Expression Regulation, Neoplastic/genetics; Humans; MAP Kinase Signaling System/drug effects; Membrane Potential, Mitochondrial/drug effects; Membrane Potential, Mitochondrial/genetics; Nitrobenzenes/pharmacology; Ovarian Neoplasms/drug therapy; Ovarian Neoplasms/genetics; Ovarian Neoplasms/pathology; Phosphorylation/drug effects; Phosphorylation/genetics; RNA, Small Interfering; Resveratrol; Sulfonamides/pharmacology; Tumor Suppressor Protein p53/genetics; Tumor Suppressor Protein p53/metabolism; p38 Mitogen-Activated Protein Kinases/genetics; p38 Mitogen-Activated Protein Kinases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms / Stilbenes / Gene Expression Regulation, Enzymologic / Gene Expression Regulation, Neoplastic / Ceramides / Anti-Inflammatory Agents, Non-Steroidal / Apoptosis / Cyclooxygenase 2 Limits: Female / Humans Language: En Journal: J Cell Biochem Year: 2013 Type: Article Affiliation country: Taiwan

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