No evidence for transgenerational genomic instability in the F1 or F2 descendants of Muta&#8482;Mouse males exposed to N-ethyl-N-nitrosourea.

O'Brien, Jason M; Williams, Andrew; Gingerich, John; Douglas, George R; Marchetti, Francesco; Yauk, Carole L

No evidence for transgenerational genomic instability in the F1 or F2 descendants of Muta™Mouse males exposed to N-ethyl-N-nitrosourea.

O'Brien, Jason M; Williams, Andrew; Gingerich, John; Douglas, George R; Marchetti, Francesco; Yauk, Carole L.

Affiliation

O'Brien JM; Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON K1A 0K9, Canada.

Mutat Res ; 741-742: 11-7, 2013.

Article in En | MEDLINE | ID: mdl-23499255

Subject(s)

Alkylating Agents/toxicity; Chromosome Breakage/drug effects; Ethylnitrosourea/toxicity; Genomic Instability/drug effects; Inheritance Patterns/genetics; Prenatal Exposure Delayed Effects/chemically induced; Spermatozoa/drug effects; Animals; DNA Damage; Female; Genomic Instability/genetics; Germ Cells/drug effects; Lac Operon; Male; Mice; Mice, Mutant Strains; Mutation/genetics; Pregnancy; Prenatal Exposure Delayed Effects/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prenatal Exposure Delayed Effects / Spermatozoa / Chromosome Breakage / Inheritance Patterns / Genomic Instability / Alkylating Agents / Ethylnitrosourea Limits: Animals / Pregnancy Language: En Journal: Mutat Res Year: 2013 Type: Article Affiliation country: Canada

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