Systemic release of high mobility group box 1 (HMGB1) protein is associated with severe and fatal Plasmodium falciparum malaria.

Higgins, Sarah J; Xing, Katharine; Kim, Hani; Kain, Dylan C; Wang, Feng; Dhabangi, Aggrey; Musoke, Charles; Cserti-Gazdewich, Christine M; Tracey, Kevin J; Kain, Kevin C; Liles, W Conrad

Higgins, Sarah J; Xing, Katharine; Kim, Hani; Kain, Dylan C; Wang, Feng; Dhabangi, Aggrey; Musoke, Charles; Cserti-Gazdewich, Christine M; Tracey, Kevin J; Kain, Kevin C; Liles, W Conrad.

Affiliation

Higgins SJ; Sandra A Rotman Laboratory, McLaughlin-Rotman Centre for Global Health, University Health Network/University of Toronto, Toronto, ON, Canada.

Malar J ; 12: 105, 2013 Mar 19.

Article in En | MEDLINE | ID: mdl-23506269

Subject(s)

Biomarkers/blood; HMGB1 Protein/blood; Malaria, Falciparum/pathology; Animals; Antibodies, Neutralizing/administration & dosage; Case-Control Studies; Child; Child, Preschool; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunoglobulins, Intravenous/administration & dosage; Infant; Malaria/drug therapy; Malaria/pathology; Malaria, Falciparum/mortality; Male; Mice; Mice, Inbred C57BL; Prognosis; Prospective Studies; ROC Curve; Treatment Outcome; Uganda

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biomarkers / Malaria, Falciparum / HMGB1 Protein Type of study: Evaluation_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Child / Child, preschool / Female / Humans / Infant / Male Country/Region as subject: Africa Language: En Journal: Malar J Journal subject: MEDICINA TROPICAL Year: 2013 Type: Article Affiliation country: Canada

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