Pharmacogenomics and translational simulations to bridge indications for an anti-interferon-&#945; receptor antibody.

Wang, B; Higgs, B W; Chang, L; Vainshtein, I; Liu, Z; Streicher, K; Liang, M; White, W I; Yoo, S; Richman, L; Jallal, B; Roskos, L; Yao, Y

Pharmacogenomics and translational simulations to bridge indications for an anti-interferon-α receptor antibody.

Wang, B; Higgs, B W; Chang, L; Vainshtein, I; Liu, Z; Streicher, K; Liang, M; White, W I; Yoo, S; Richman, L; Jallal, B; Roskos, L; Yao, Y.

Affiliation

Wang B; Department of Translational Sciences, MedImmune, LLC, Gaithersburg, Maryland, USA.

Clin Pharmacol Ther ; 93(6): 483-92, 2013 Jun.

Article in En | MEDLINE | ID: mdl-23511714

Subject(s)

Antibodies, Monoclonal/therapeutic use; Computer Simulation; Interferon-alpha/metabolism; Pharmacogenetics; Receptor, Interferon alpha-beta/immunology; Receptor, Interferon alpha-beta/metabolism; Scleroderma, Systemic/drug therapy; Adult; Aged; Antibodies, Monoclonal/immunology; Antibodies, Monoclonal/pharmacokinetics; Antibodies, Monoclonal/pharmacology; Antibodies, Monoclonal, Humanized; Biomarkers/blood; Biomarkers/metabolism; Clinical Trials, Phase II as Topic; Dose-Response Relationship, Drug; Female; Humans; Interferon-alpha/genetics; Lupus Erythematosus, Systemic/drug therapy; Male; Middle Aged; Models, Biological; Scleroderma, Systemic/blood; Scleroderma, Systemic/metabolism; Skin/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pharmacogenetics / Scleroderma, Systemic / Computer Simulation / Interferon-alpha / Receptor, Interferon alpha-beta / Antibodies, Monoclonal Type of study: Clinical_trials / Prognostic_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Clin Pharmacol Ther Year: 2013 Type: Article Affiliation country: United States

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