Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.

Son, Jaekyoung; Lyssiotis, Costas A; Ying, Haoqiang; Wang, Xiaoxu; Hua, Sujun; Ligorio, Matteo; Perera, Rushika M; Ferrone, Cristina R; Mullarky, Edouard; Shyh-Chang, Ng; Kang, Ya'an; Fleming, Jason B; Bardeesy, Nabeel; Asara, John M; Haigis, Marcia C; DePinho, Ronald A; Cantley, Lewis C; Kimmelman, Alec C

Son, Jaekyoung; Lyssiotis, Costas A; Ying, Haoqiang; Wang, Xiaoxu; Hua, Sujun; Ligorio, Matteo; Perera, Rushika M; Ferrone, Cristina R; Mullarky, Edouard; Shyh-Chang, Ng; Kang, Ya'an; Fleming, Jason B; Bardeesy, Nabeel; Asara, John M; Haigis, Marcia C; DePinho, Ronald A; Cantley, Lewis C; Kimmelman, Alec C.

Affiliation

Son J; Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.

Nature ; 496(7443): 101-5, 2013 Apr 04.

Article in En | MEDLINE | ID: mdl-23535601

Subject(s)

Glutamine/metabolism; Metabolic Networks and Pathways; Oncogene Protein p21(ras)/metabolism; Pancreatic Neoplasms/metabolism; Pancreatic Neoplasms/pathology; Proto-Oncogene Proteins/metabolism; ras Proteins/metabolism; Adenocarcinoma/genetics; Adenocarcinoma/metabolism; Adenocarcinoma/pathology; Aspartate Aminotransferases/deficiency; Aspartate Aminotransferases/genetics; Aspartate Aminotransferases/metabolism; Cell Line, Tumor; Cell Proliferation; Citric Acid Cycle; Glutamate Dehydrogenase/metabolism; Homeostasis; Humans; Ketoglutaric Acids/metabolism; Oncogene Protein p21(ras)/genetics; Oncogenes/genetics; Oxidation-Reduction; Pancreatic Neoplasms/genetics; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins p21(ras); Reactive Oxygen Species/metabolism; ras Proteins/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Oncogene Protein p21(ras) / Proto-Oncogene Proteins / Ras Proteins / Metabolic Networks and Pathways / Glutamine Limits: Humans Language: En Journal: Nature Year: 2013 Type: Article Affiliation country: United States

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