TAK-441, a novel investigational smoothened antagonist, delays castration-resistant progression in prostate cancer by disrupting paracrine hedgehog signaling.

Ibuki, Naokazu; Ghaffari, Mazyar; Pandey, Mitali; Iu, Irene; Fazli, Ladan; Kashiwagi, Masahide; Tojo, Hideaki; Nakanishi, Osamu; Gleave, Martin E; Cox, Michael E

Ibuki, Naokazu; Ghaffari, Mazyar; Pandey, Mitali; Iu, Irene; Fazli, Ladan; Kashiwagi, Masahide; Tojo, Hideaki; Nakanishi, Osamu; Gleave, Martin E; Cox, Michael E.

Affiliation

Ibuki N; The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, British Columbia, Canada.

Int J Cancer ; 133(8): 1955-66, 2013 Oct 15.

Article in En | MEDLINE | ID: mdl-23564295

Subject(s)

Antineoplastic Agents/pharmacology; Paracrine Communication/drug effects; Prostatic Neoplasms/drug therapy; Pyridines/pharmacology; Pyrroles/pharmacology; Receptors, G-Protein-Coupled/antagonists & inhibitors; Animals; Castration; Cell Line, Tumor; Cell Proliferation/drug effects; Disease Progression; Hedgehog Proteins/antagonists & inhibitors; Hedgehog Proteins/metabolism; Humans; Male; Mice; Mice, Nude; Neoplasm Transplantation; Prostatic Neoplasms/metabolism; Smoothened Receptor; Tumor Microenvironment/drug effects; Veratrum Alkaloids/pharmacology; Xenograft Model Antitumor Assays

Key words

hedgehog signaling; prostate cancer; small molecule inhibitor; smoothened

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Pyridines / Pyrroles / Paracrine Communication / Receptors, G-Protein-Coupled / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Int J Cancer Year: 2013 Type: Article Affiliation country: Canada

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