Heterogeneous sensitivity of hepatocellular carcinoma to sorafenib revealed by the short-term culture of tumor fragments.

Godin, Corinne; Dupont, Sebastien; Ezzoukhry, Zakaria; Louandre, Christophe; Chatelain, Denis; Henaut, Lucie; Sabbagh, Charles; Regimbeau, Jean-Marc; Maziere, Jean-Claude; Barbare, Jean-Claude; Chauffert, Bruno; Galmiche, Antoine

Godin, Corinne; Dupont, Sebastien; Ezzoukhry, Zakaria; Louandre, Christophe; Chatelain, Denis; Henaut, Lucie; Sabbagh, Charles; Regimbeau, Jean-Marc; Maziere, Jean-Claude; Barbare, Jean-Claude; Chauffert, Bruno; Galmiche, Antoine.

Affiliation

Godin C; Inserm U1088, University of Picardie Jules Verne, Amiens, France.

Anticancer Res ; 33(4): 1415-20, 2013 Apr.

Article in En | MEDLINE | ID: mdl-23564781

Subject(s)

Antineoplastic Agents/pharmacology; Carcinoma, Hepatocellular/drug therapy; Drug Resistance, Neoplasm; Liver Neoplasms/drug therapy; Niacinamide/analogs & derivatives; Phenylurea Compounds/pharmacology; Aged; Aged, 80 and over; Animals; Carcinoma, Hepatocellular/metabolism; Carcinoma, Hepatocellular/pathology; Female; Humans; Immunoblotting; Liver Neoplasms/metabolism; Liver Neoplasms/pathology; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Mitogen-Activated Protein Kinase 1/metabolism; Mitogen-Activated Protein Kinase 3/metabolism; Niacinamide/pharmacology; Phosphorylation/drug effects; Sorafenib; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Phenylurea Compounds / Niacinamide / Carcinoma, Hepatocellular / Drug Resistance, Neoplasm / Liver Neoplasms / Antineoplastic Agents Type of study: Diagnostic_studies Limits: Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Language: En Journal: Anticancer Res Year: 2013 Type: Article Affiliation country: France

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