Chemokine receptor CXCR6-dependent hepatic NK T Cell accumulation promotes inflammation and liver fibrosis.

Wehr, Alexander; Baeck, Christer; Heymann, Felix; Niemietz, Patricia Maria; Hammerich, Linda; Martin, Christian; Zimmermann, Henning W; Pack, Oliver; Gassler, Nikolaus; Hittatiya, Kanishka; Ludwig, Andreas; Luedde, Tom; Trautwein, Christian; Tacke, Frank

Wehr, Alexander; Baeck, Christer; Heymann, Felix; Niemietz, Patricia Maria; Hammerich, Linda; Martin, Christian; Zimmermann, Henning W; Pack, Oliver; Gassler, Nikolaus; Hittatiya, Kanishka; Ludwig, Andreas; Luedde, Tom; Trautwein, Christian; Tacke, Frank.

Affiliation

Wehr A; Department of Medicine III, University-Hospital Aachen, 52074 Aachen, Germany.

J Immunol ; 190(10): 5226-36, 2013 May 15.

Article in En | MEDLINE | ID: mdl-23596313

Subject(s)

Chemokine CXCL6/metabolism; Liver Cirrhosis/immunology; Natural Killer T-Cells/immunology; Receptors, CXCR/metabolism; Adoptive Transfer; Animals; CD4-Positive T-Lymphocytes/immunology; Cell Movement; Cells, Cultured; Chemokine CXCL16; Chemokine CXCL6/biosynthesis; Chemokine CXCL6/blood; Fatty Liver; Hepatocytes/immunology; Humans; Inflammation/immunology; Interferon-gamma/biosynthesis; Interleukin-4/biosynthesis; Liver/immunology; Liver/injuries; Liver/metabolism; Liver Cirrhosis/metabolism; Liver Diseases/metabolism; Macrophages/immunology; Mice; Mice, Inbred C57BL; Mice, Knockout; Natural Killer T-Cells/metabolism; Receptors, CXCR/biosynthesis; Receptors, CXCR/genetics; Receptors, CXCR6; Up-Regulation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chemokine CXCL6 / Receptors, CXCR / Natural Killer T-Cells / Liver Cirrhosis Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Immunol Year: 2013 Type: Article Affiliation country: Germany

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