Low FasL levels promote proliferation of human bone marrow-derived mesenchymal stem cells, higher levels inhibit their differentiation into adipocytes.

Rippo, M R; Babini, L; Prattichizzo, F; Graciotti, L; Fulgenzi, G; Tomassoni Ardori, F; Olivieri, F; Borghetti, G; Cinti, S; Poloni, A; Fazioli, F; Procopio, A D

Rippo, M R; Babini, L; Prattichizzo, F; Graciotti, L; Fulgenzi, G; Tomassoni Ardori, F; Olivieri, F; Borghetti, G; Cinti, S; Poloni, A; Fazioli, F; Procopio, A D.

Affiliation

Rippo MR; Laboratory of Experimental Pathology, Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy. m.r.rippo@univpm.it

Cell Death Dis ; 4: e594, 2013 Apr 18.

Article in En | MEDLINE | ID: mdl-23598406

Subject(s)

Adipogenesis/drug effects; Bone Marrow Cells/cytology; Fas Ligand Protein/pharmacology; Mesenchymal Stem Cells/cytology; Animals; Antibodies, Neutralizing/immunology; Caspases/metabolism; Cell Proliferation/drug effects; Cells, Cultured; Fas Ligand Protein/genetics; Fas Ligand Protein/metabolism; Fatty Acid-Binding Proteins/metabolism; Humans; Inhibitor of Apoptosis Proteins/metabolism; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitogen-Activated Protein Kinase 1/metabolism; Mitogen-Activated Protein Kinase 3/metabolism; PPAR gamma/metabolism; Recombinant Proteins/biosynthesis; Recombinant Proteins/genetics; Recombinant Proteins/pharmacology; Survivin; Tibia/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bone Marrow Cells / Adipogenesis / Fas Ligand Protein / Mesenchymal Stem Cells Limits: Animals / Humans Language: En Journal: Cell Death Dis Year: 2013 Type: Article Affiliation country: Italy

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