A nucleus-targeted alternately spliced Nix/Bnip3L protein isoform modifies nuclear factor &#954;B (NF&#954;B)-mediated cardiac transcription.

Chen, Yun; Decker, Keith F; Zheng, Dali; Matkovich, Scot J; Jia, Li; Dorn, Gerald W

A nucleus-targeted alternately spliced Nix/Bnip3L protein isoform modifies nuclear factor κB (NFκB)-mediated cardiac transcription.

Chen, Yun; Decker, Keith F; Zheng, Dali; Matkovich, Scot J; Jia, Li; Dorn, Gerald W.

Affiliation

Chen Y; Center for Pharmacogenomics, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

J Biol Chem ; 288(22): 15455-65, 2013 May 31.

Article in En | MEDLINE | ID: mdl-23603904

Subject(s)

Alternative Splicing/physiology; Cell Nucleus/metabolism; Membrane Proteins/metabolism; Mitochondrial Proteins/metabolism; Muscle Proteins/metabolism; Myoblasts, Cardiac/metabolism; Proto-Oncogene Proteins/metabolism; Transcription Factor RelA/metabolism; Transcription, Genetic/physiology; Active Transport, Cell Nucleus/physiology; Animals; Cell Line; Cell Nucleus/genetics; Gene Expression Regulation/physiology; Membrane Proteins/genetics; Mice; Mice, Mutant Strains; Mitochondrial Proteins/genetics; Muscle Proteins/genetics; Myoblasts, Cardiac/cytology; Protein Isoforms/genetics; Protein Isoforms/metabolism; Proto-Oncogene Proteins/genetics; Transcription Factor RelA/genetics; Tumor Necrosis Factor-alpha/genetics; Tumor Necrosis Factor-alpha/metabolism

Key words

Bcl-2 Family Proteins; Cardiovascular Disease; Gene Regulation; NF-kappa B (NF-KB); Tumor Necrosis Factor (TNF); sNix

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription, Genetic / Cell Nucleus / Proto-Oncogene Proteins / Alternative Splicing / Mitochondrial Proteins / Myoblasts, Cardiac / Transcription Factor RelA / Membrane Proteins / Muscle Proteins Limits: Animals Language: En Journal: J Biol Chem Year: 2013 Type: Article Affiliation country: United States

Fulltext

XML

PubMed Links

Search on Google