Alantolactone induces apoptosis in chronic myelogenous leukemia sensitive or resistant to imatinib through NF-&#954;B inhibition and Bcr/Abl protein deletion.

Wei, Wei; Huang, He; Zhao, Shan; Liu, Wei; Liu, Chuan-Xu; Chen, Li; Li, Jun-Min; Wu, Ying-Li; Yan, Hua

Alantolactone induces apoptosis in chronic myelogenous leukemia sensitive or resistant to imatinib through NF-κB inhibition and Bcr/Abl protein deletion.

Wei, Wei; Huang, He; Zhao, Shan; Liu, Wei; Liu, Chuan-Xu; Chen, Li; Li, Jun-Min; Wu, Ying-Li; Yan, Hua.

Affiliation

Wei W; Department of Hematology, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, No. 197, Ruijin Er Road, Shanghai, 200025, China.

Apoptosis ; 18(9): 1060-70, 2013 Sep.

Article in En | MEDLINE | ID: mdl-23613107

Subject(s)

Apoptosis/drug effects; Benzamides/pharmacology; Drug Resistance, Neoplasm; Fusion Proteins, bcr-abl/genetics; Gene Deletion; Lactones/pharmacology; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics; NF-kappa B/antagonists & inhibitors; Piperazines/pharmacology; Pyrimidines/pharmacology; Sesquiterpenes, Eudesmane/pharmacology; Animals; Cell Line, Tumor; Cell Proliferation/drug effects; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/metabolism; Mice; NF-kappa B/genetics; NF-kappa B/metabolism; Signal Transduction/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Pyrimidines / Benzamides / Leukemia, Myelogenous, Chronic, BCR-ABL Positive / NF-kappa B / Fusion Proteins, bcr-abl / Gene Deletion / Apoptosis / Drug Resistance, Neoplasm / Sesquiterpenes, Eudesmane Type of study: Diagnostic_studies Limits: Animals / Humans Language: En Journal: Apoptosis Year: 2013 Type: Article Affiliation country: China

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