LIM kinase-1 selectively promotes glycoprotein Ib-IX-mediated TXA2 synthesis, platelet activation, and thrombosis.

Estevez, Brian; Stojanovic-Terpo, Aleksandra; Delaney, M Keegan; O'Brien, Kelly A; Berndt, Michael C; Ruan, Changgeng; Du, Xiaoping

Estevez, Brian; Stojanovic-Terpo, Aleksandra; Delaney, M Keegan; O'Brien, Kelly A; Berndt, Michael C; Ruan, Changgeng; Du, Xiaoping.

Affiliation

Estevez B; Department of Pharmacology, University of Illinois at Chicago College of Medicine, Chicago, IL 60612, USA.

Blood ; 121(22): 4586-94, 2013 May 30.

Article in En | MEDLINE | ID: mdl-23620575

Subject(s)

Lim Kinases/metabolism; Platelet Activation/physiology; Platelet Glycoprotein GPIb-IX Complex/metabolism; Thrombosis/metabolism; Thromboxane A2/biosynthesis; Actin Depolymerizing Factors/metabolism; Actins/metabolism; Animals; Blood Platelets/metabolism; Cell Adhesion/physiology; Drug Design; Fibrinolytic Agents/metabolism; Hemorrhage/drug therapy; Hemorrhage/metabolism; Humans; Lim Kinases/genetics; Mice; Mice, Inbred C57BL; Mice, Knockout; Stress, Mechanical; Thromboxane A2/metabolism; von Willebrand Factor/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thrombosis / Thromboxane A2 / Platelet Activation / Platelet Glycoprotein GPIb-IX Complex / Lim Kinases Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Blood Year: 2013 Type: Article Affiliation country: United States

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