Hypofunction of glutamatergic neurotransmission in the periaqueductal gray contributes to nerve-injury-induced neuropathic pain.

Ho, Yu-Cheng; Cheng, Jen-Kun; Chiou, Lih-Chu

Ho, Yu-Cheng; Cheng, Jen-Kun; Chiou, Lih-Chu.

Affiliation

Ho YC; Graduate Institute, Department of Pharmacology, Graduate Institute of Brain and Mind Sciences, College of Medicine, Neurobiology and Cognitive Science Center, National Taiwan University, Taipei 10051, Taiwan.

J Neurosci ; 33(18): 7825-36, 2013 May 01.

Article in En | MEDLINE | ID: mdl-23637174

Subject(s)

Glutamic Acid/metabolism; Neuralgia/pathology; Periaqueductal Gray/physiopathology; Synaptic Transmission/physiology; Animals; Bicuculline/pharmacology; Disease Models, Animal; Electric Stimulation; Excitatory Amino Acid Agents/pharmacology; Excitatory Postsynaptic Potentials/drug effects; Excitatory Postsynaptic Potentials/physiology; In Vitro Techniques; Male; Membrane Potentials/drug effects; Membrane Potentials/physiology; Neuralgia/etiology; Neurons/drug effects; Neurons/physiology; Pain Measurement; Patch-Clamp Techniques; Periaqueductal Gray/pathology; Rats; Rats, Sprague-Dawley; Receptors, Glutamate/metabolism; Spinal Nerves/injuries; Synaptic Transmission/drug effects; Tetrodotoxin/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Periaqueductal Gray / Synaptic Transmission / Glutamic Acid / Neuralgia Type of study: Etiology_studies Limits: Animals Language: En Journal: J Neurosci Year: 2013 Type: Article Affiliation country: Taiwan

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