Obesity induces hypothalamic endoplasmic reticulum stress and impairs proopiomelanocortin (POMC) post-translational processing.

Cakir, Isin; Cyr, Nicole E; Perello, Mario; Litvinov, Bogdan Patedakis; Romero, Amparo; Stuart, Ronald C; Nillni, Eduardo A

Cakir, Isin; Cyr, Nicole E; Perello, Mario; Litvinov, Bogdan Patedakis; Romero, Amparo; Stuart, Ronald C; Nillni, Eduardo A.

Affiliation

Cakir I; Division of Endocrinology, Department of Medicine, Warren Alpert Medical School of Brown University/Rhode Island Hospital, Providence, Rhode Island 02907, USA.

J Biol Chem ; 288(24): 17675-88, 2013 Jun 14.

Article in En | MEDLINE | ID: mdl-23640886

Subject(s)

Arcuate Nucleus of Hypothalamus/metabolism; Endoplasmic Reticulum Stress; Obesity/metabolism; Pro-Opiomelanocortin/metabolism; Protein Processing, Post-Translational; Adrenocorticotropic Hormone/metabolism; Animals; Arcuate Nucleus of Hypothalamus/pathology; Cell Line; Diet, High-Fat/adverse effects; Endoplasmic Reticulum/metabolism; Gene Expression Regulation; Leptin/physiology; Male; Mice; Obesity/etiology; Obesity/pathology; Pro-Opiomelanocortin/genetics; Proprotein Convertase 2/metabolism; Protein Tyrosine Phosphatase, Non-Receptor Type 1/genetics; Protein Tyrosine Phosphatase, Non-Receptor Type 1/metabolism; Rats; Rats, Sprague-Dawley; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins/genetics; Suppressor of Cytokine Signaling Proteins/metabolism; alpha-MSH/metabolism; eIF-2 Kinase/genetics; eIF-2 Kinase/metabolism

Key words

Endoplasmic Reticulum Stress; Energy Metabolism; Hypothalamus; Neuropeptide; Protein Processing

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arcuate Nucleus of Hypothalamus / Pro-Opiomelanocortin / Protein Processing, Post-Translational / Endoplasmic Reticulum Stress / Obesity Type of study: Etiology_studies / Prognostic_studies Limits: Animals Language: En Journal: J Biol Chem Year: 2013 Type: Article Affiliation country: United States

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